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CAS No 11015-37-5 , Flavomycin

  • Name: Flavomycin
  • Synonyms: Bambermycin; Flavophospholipol; Moenomycin A;Flavomycin;
  • CAS Registry Number:
  • Density: 1.47 g/cm3
  • Refractive index: 1.615
  • Safety Statements: Poison by intravenous route. Moderately toxic by subcutaneous route.
  • EINECS: 234-246-7
  • Molecular Weight: 1583.57
  • InChI: InChI=1/C69H107N4O35P/c1-30(2)15-14-17-31(3)18-19-33(5)22-25-68(9,10)24-13-12-16-32(4)23-26-96-41(60(88)89)29-98-109(94,95)108-66-56(57(107-67(70)92)69(11,93)58(106-66)61(90)91)105-63-44(72-36(8)76)47(81)54(40(101-63)28-97-64-51(85)48(82)45(79)39(27-74)100-64)103-62-43(71-35(7)75)46(80)53(34(6)99-62)102-65-52(86)49(83)50(84)55(104-65)59(87)73-42-37(77)20-21-38(42)78/h13,15,18,23-24,34,39-41,43-58,62-66,74,77,79-86,93H,5,12,14,16-17,19-22,25-29H2,1-4,6-11H3,(H2,70,92)(H,71,75)(H,72,76)(H,73,87)(H,88,89)(H,90,91)(H,94,95)/b24-13+,31-18+,32-23+/t34-,39-,40-,41-,43-,44-,45-,46-,47-,48+,49+,50-,51-,52-,53-,54-,55+,56-,57-,58-,62+,63+,64-,65-,66-,69+/m1/s1
  • Molecular Formula: C69H107N4O35P
  • Molecular Structure:CAS No:11015-37-5 Flavomycin

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References of Flavomycin
Title: Bambermycins
CAS Registry Number: 11015-37-5
Synonyms: Moenomycin; flavophospholipol
Trademarks: Flavomycin (Hoechst)
Literature References: Antibiotic complex comprised of at least 4 active components, moenomycins A, B1, B2 and C, with moenomycin A being the major component. Obtained from cultures of Streptomyces bambergiensis, S. ghanaensis, S. ederensis, S. geysiriensis and related strains: Wallh?user et al., Antimicrob. Agents Chemother. 1965, 734 sqq.; NL 6602132 C.A. 66, 74946x (1967) and Lindner, Wallh?user, US 3674866 (1966, 1972 both to Hoechst). Structural studies: Tschesche et al., Ann. 720, 58 (1968); Tetrahedron Lett. 1968, 2905; 1969, 141; Huber, J. Antibiot. 25, 1226 (1972); P. Welzel et al., Tetrahedron Lett. 1973, 227; F. J. Witteler et al., ibid. 1979, 3493; P. Welzel et al., Tetrahedron 39, 1583 (1983). Structure of moenomycin A: P. Welzel et al., Angew. Chem. Int. Ed. 20, 121 (1981). Synthesis of moenocinol, the lipid moiety: Tschesche, Reden, Ann. 1974, 853; P. J. Kocienski, J. Org. Chem. 45, 2037 (1980); R. M. Coates, M. W. Johnson, ibid. 2685. Review: G. Huber in Antibiotics vol. 5, pt. 1, F. E. Hahn, Ed. (Springer-Verlag, New York, 1979) pp 135-153.
Properties: Complex is a colorless, amorphous solid, no definite mp, decompn starting at 200°C. uv max (water pH 7): 258 nm (E1%1cm 60). Sol in water, methanol, DMF; less sol in ethanol, propanol; slightly sol in ether, ethyl acetate. Insol in benzene, chloroform. Stable in neutral aq and methanolic solns; slowly decomp in acid and alkaline solns. LD50 in mice (mg/kg): >2000 orally, s.c. and i.p.; 1400 i.v. (Lindner, Wallh?user).
Absorption maximum: uv max (water pH 7): 258 nm (E1%1cm 60)
Toxicity data: LD50 in mice (mg/kg): >2000 orally, s.c. and i.p.; 1400 i.v. (Lindner, Wallh?user)
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial; feed additive (poultry, swine and calves).
Keywords: Antibacterial (Antibiotics); Aminoglycosides.