Title: Granisetron
CAS Registry Number: 109889-09-0
CAS Name: 1-Methyl-
N-[(3-
endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1
H-indazole-3-carboxamide
Molecular Formula: C18H24N4O
Molecular Weight: 312.41
Percent Composition: C 69.20%, H 7.74%, N 17.93%, O 5.12%
Literature References: Specific serotonin (5HT3) receptor antagonist. Prepn: F. D. King,
EP 200444;
idem, US 4886808 (1986, 1989 both to Beecham). 5HT3 receptor binding study: G. J. Kilpatrick
et al., Nature 330, 746 (1987). Series of articles on pharmacology and clinical trials to prevent chemotherapy-induced emesis:
Semin. Oncol. 22, Suppl. 10, 1-30 (1995).
Derivative Type: Hydrochloride
CAS Registry Number: 107007-99-8
Manufacturers' Codes: BRL-43694A
Trademarks: Kytril (SKB)
Molecular Formula: C18H24N4O.HCl
Molecular Weight: 348.87
Percent Composition: C 61.97%, H 7.22%, N 16.06%, O 4.59%, Cl 10.16%
Properties: White to off-white solid, mp 290-292°. Readily sol in water at 20°.
Melting point: mp 290-292°
Therap-Cat: Antiemetic.
Keywords: Antiemetic; Serotonin Receptor Antagonist.