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CAS No 107233-08-9 , Cevimeline

  • Name: Cevimeline
  • Synonyms: AF 102B; Cevimeline [INN]; AF-102B; Fks 508;Cevimeline; Saligren;Evoxac; Cevimeline (INN); Cevimeline hydrochloride; 107233-08-9;
  • CAS Registry Number:
  • Density: 1.19
  • Refractive index: 1.586
  • Molecular Weight: 199.31308
  • InchiKey: WUTYZMFRCNBCHQ-PSASIEDQSA-N
  • InChI: InChI=1/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8?,10-/m1/s1
  • Molecular Formula: C10H17NOS
  • Molecular Structure:CAS No:107233-08-9 Cevimeline

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References of Cevimeline
Title: Cevimeline
CAS Registry Number: 107233-08-9
CAS Name: (2￠R,3R)-rel-2￠-Methylspiro[1-azabicyclo[2.2.2]octane-3,5￠-[1,3]oxathiolane]
Synonyms: (±)-cis-2-methylspiro[1,3-oxathiolane-5,3￠-quinuclidine]
Molecular Formula: C10H17NOS
Molecular Weight: 199.31
Percent Composition: C 60.26%, H 8.60%, N 7.03%, O 8.03%, S 16.09%
Literature References: Muscarinic M1 and M3 receptor agonist. Prepn: A. Fisher et al., JP Kokai 61 280497; eidem, US 4855290; (1986, 1989 both to State of Israel). Improved process: K. Hayashi et al., US 5571918 (1996 to Ishihara Sangyo Kaisha). Sialogogic effect in animals: H. Masunaga et al., Eur. J. Pharmacol. 339, 1 (1997). General pharmacology: H. Arisawa et al., Arzneim.-Forsch. 52, 14, 81 (2002). Clinical experience in Sj?gren's syndrome dry eye: M. Ono et al., Am. J. Ophthalmol. 138, 6 (2004); in dry mouth: K. Suzuki et al., Pharmacology 74, 100 (2005). Review of clinical pharmacokinetics and efficacy in Sj?gren's syndrome: H. Yasuda, H. Niki, Clin. Drug Invest. 22, 67-73 (2002).
 
Derivative Type: Hydrochloride hemihydrate
CAS Registry Number: 153504-70-2; 107220-28-0 (anhydrous)
Manufacturers' Codes: AF-102B; SNI-2011
Trademarks: Evoxac (Daiichi)
Molecular Formula: C10H17NOS.HCl.?H2O
Molecular Weight: 244.78
Percent Composition: C 49.07%, H 7.82%, N 5.72%, O 9.80%, S 13.10%, Cl 14.48%
Properties: White to off white crystalline powder, mp 201-203°. Freely sol in alcohol, chloroform; very sol in water. Virtually insol in ether.
Melting point: mp 201-203°
 
Therap-Cat: Sialagogue.
Keywords: Sialagogue.