Home > Name List By 3 > 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6, 7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one China

CAS No 106266-06-2 , 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,
7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Search by region : China

  • Name: 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,
    7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
  • Synonyms: Risperidal M-Tab; Risperin; Sequinan; Rispolept; Rispolin;Risperdal; Risperdal M-Tab;3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,
    7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one; Risperdal Consta; Risperidal;
  • CAS Registry Number:
  • Transport: 25kgs
  • Density: 1.38 g/cm3
  • Refractive index: 1.676
  • Safety Statements: 28-36-45
  • Hazard Symbols: T: Toxic;
  • Molecular Weight: 410.484483
  • InchiKey: RAPZEAPATHNIPO-UHFFFAOYSA-N
  • InChI: InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-
    7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,
    1H3
  • Risk Statements: 25
  • Molecular Formula: C23H27FN4O2
  • Molecular Structure:CAS No:106266-06-2 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,<br />7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one

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References of 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,
7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
Title: Risperidone
CAS Registry Number: 106266-06-2
CAS Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Manufacturers' Codes: R-64766
Trademarks: Belivon (Organon); Risperdal (J & J)
Molecular Formula: C23H27FN4O2
Molecular Weight: 410.48
Percent Composition: C 67.30%, H 6.63%, F 4.63%, N 13.65%, O 7.80%
Literature References: Combined serotonin (5-HT2) and dopamine (D2) receptor antagonist. Prepn: L. E. J. Kennis, J. Vandenberk, EP 196132; eidem, US 4804663 (1986, 1989 both to Janssen). Pharmacology: P. A. J. Janssen et al., J. Pharmacol. Exp. Ther. 244, 685 (1988). Receptor binding studies: J. E. Leysen et al., ibid. 247, 661 (1988). HPLC determn in plasma: A. Avenoso et al., J. Chromatogr. B 746, 173 (2000). Clinical study in psychoses: Y. G. Gelders et al., Pharmacopsychiatry 23, 206 (1990); in autism: L. Scahill et al., N. Engl. J. Med. 347, 314 (2002). Brief review: M. G. Livingston, Lancet 343, 457-460 (1994). Review of pharmacology and therapeutic potential: S. Grant, A. Fitton, Drugs 48, 253-273 (1994); B. Green, Curr. Med. Res. Opin. 16, 57-65 (2000); of clinical experience in schizophrenia: H.-J. M?ller, Expert Opin. Pharmacother. 6, 803-818 (2005),
Properties: Crystals from DMF + 2-propanol, mp 170.0°. LD50 in male, female mice, rats, dogs (mg/kg): 29.7, 26.9, 34.3, 35.4, 14.1, 18.3 i.v.; 82.1, 63.1, 113, 56.6, 18.3, 18.3 orally (Janssen, 1988).
Melting point: mp 170.0°
Toxicity data: LD50 in male, female mice, rats, dogs (mg/kg): 29.7, 26.9, 34.3, 35.4, 14.1, 18.3 i.v.; 82.1, 63.1, 113, 56.6, 18.3, 18.3 orally (Janssen, 1988)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Benzisoxazoles; Serotonin-Dopamine Antagonist.