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CAS No 10596-23-3 , [dichloro(phosphono)methyl]phosphonic acid

  • Name: [dichloro(phosphono)methyl]phosphonic acid
  • Synonyms: Clodronate; Acido clodronico; Dichloromethanediphosphonic acid;[dichloro(phosphono)methyl]phosphonic acid; Dichloromethylidene diphosphonate; Clodronsaeure; Bonefos; Acide clodronique;
  • CAS Registry Number:
  • Flash Point: 240.9°C
  • Boiling Point: 474.7°Cat760mmHg
  • Density: 2.306g/cm3
  • Refractive index: 1.598
  • Flash Point: 240.9°C
  • EINECS: 234-212-1
  • Molecular Weight: 244.892384
  • InchiKey: ACSIXWWBWUQEHA-UHFFFAOYSA-N
  • InChI: InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
  • Molecular Formula: CH4Cl2O6P2
  • Molecular Structure:CAS No:10596-23-3 [dichloro(phosphono)methyl]phosphonic acid

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10596-23-3 Clodronic Acid

  • We provide Clodronic Acid for pharmaceutical study Molecular Formula:CH4Cl2O6P2 Formula Weight:244.89 We can provide with commercial quantity, welcome to inquire!
  • China Shanghai BociMed Pharmaceutical Co., Ltd. [Manufacturer]
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10596-23-3 Clodronic Acid

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10596-23-3 CLODRONIC ACID

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of [dichloro(phosphono)methyl]phosphonic acid
Title: Clodronic Acid
CAS Registry Number: 10596-23-3
CAS Name: (Dichloromethylene)bisphosphonic acid
Synonyms: (dichloromethylene)diphosphonic acid; dichloromethanediphosphonic acid; Cl2MDP; DMDP
Molecular Formula: CH4Cl2O6P2
Molecular Weight: 244.89
Percent Composition: C 4.90%, H 1.65%, Cl 28.95%, O 39.20%, P 25.30%
Literature References: Bisphosponate antiresorptive agent. Prepn and use as detergent additive: BE 672205 (1966 to Procter and Gamble), C.A. 67, 4040u (1967). Prepn: O. T. Quimby et al., J. Org. Chem. 32, 4111 (1967). Effect on hydroxyapatite durapatite, q.v., crystal aggregation: N. M. Hansen et al., Biochim. Biophys. Acta 451, 549 (1976); S. Bisaz et al., ibid. 560. HPLC determn in urine: V. Virtanen, L. H. J. Lajunen, J. Chromatogr. 617, 291 (1993). Symposium on therapeutic efficacy in neoplastic bone disease: Bone 8, Suppl. 1, S1-S86 (1987). Review of pharmacology and clinical efficacy in resorptive bone disease: G. L. Plosker, K. L. Goa, Drugs 47, 945-982 (1994). Clinical reduction of new metastases in breast cancer: I. J. Diel et al., N. Engl. J. Med. 339, 357 (1998).
Properties: mp 249-251°.
Melting point: mp 249-251°
 
Derivative Type: Disodium salt
CAS Registry Number: 22560-50-5; 88416-50-6 (tetrahydrate)
Synonyms: Clodronate disodium
Trademarks: Bonefos (Schering AG); Clasteon (Abiogen); Clastoban (RPR); Difosfonal (SPA); Loron (Roche); Lytos (Boehringer, Mann.); Mebonat (Boehringer, Mann.); Ossiten (Boehringer, Mann.); Ostac (Boehringer, Mann.)
Molecular Formula: CH2Cl2Na2O6P2
Molecular Weight: 288.86
Percent Composition: C 4.16%, H 0.70%, Cl 24.55%, Na 15.92%, O 33.23%, P 21.45%
Properties: Occurs as the tetrahydrate.
 
Therap-Cat: Bone resorption inhibitor.
Keywords: Antiosteoporotic; Bone Resorption Inhibitor.