Home > Name List By other > (NE)-N-[(3R)-3-[[3-[[(2R,3E)-3-hydroxyiminobutan-2-yl]amino]-2, 2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine

CAS No 105613-48-7 , (NE)-N-[(3R)-3-[[3-[[(2R,3E)-3-hydroxyiminobutan-2-yl]amino]-2,
2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine

  • Name: (NE)-N-[(3R)-3-[[3-[[(2R,3E)-3-hydroxyiminobutan-2-yl]amino]-2,
    2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine
  • Synonyms: Exametazimum;105613-48-7;(NE)-N-[(3R)-3-[[3-[[(2R,3E)-3-hydroxyiminobutan-2-yl]amino]-2,
    2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine; Exametazimum [Latin]; DSSTox_RID_97289; Exametazima; Hexametazime; Exametazima [Spanish]; DSSTox_CID_31403;
  • CAS Registry Number:
  • Flash Point: 215.7°C
  • Boiling Point: 433°Cat760mmHg
  • Density: 1.06g/cm3
  • Refractive index: 1.505
  • Flash Point: 215.7°C
  • Molecular Weight: 272.38702
  • InchiKey: BPNZYADGDZPRTK-UDUYQYQQSA-N
  • InChI: InChI=1S/C13H28N4O2/c1-9(11(3)16-18)14-7-13(5,
    6)8-15-10(2)12(4)17-19/h9-10,14-15,18-19H,7-8H2,1-6H3/b16-11+,
    17-12+/t9-,10-/m1/s1
  • Molecular Formula: C13H28N4O2
  • Molecular Structure:CAS No:105613-48-7 (NE)-N-[(3R)-3-[[3-[[(2R,3E)-3-hydroxyiminobutan-2-yl]amino]-2,<br />2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine

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References of (NE)-N-[(3R)-3-[[3-[[(2R,3E)-3-hydroxyiminobutan-2-yl]amino]-2,
2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine
Title: Exametazime
CAS Registry Number: 105613-48-7
CAS Name: (2E,2￠E,3R,3￠R)-rel-3,3￠-[(2,2-Dimethyl-1,3-propanediyl)diimino]bis-2-butanone dioxime
Synonyms: (RR,SS)-4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime; (±)-(3RS,3￠RS)-3,3￠-[(2,2-dimethyltrimethylene)diimino]di-2-butanone dioxime; d,l-hexamethylpropyleneamine oxime; d,l-HM-PAO; hexametazine
Trademarks: Ceretec (Amersham)
Molecular Formula: C13H28N4O2
Molecular Weight: 272.39
Percent Composition: C 57.32%, H 10.36%, N 20.57%, O 11.75%
Literature References: Propyleneamine oxime derivative that forms a neutral, lipophilic complex with 99mTc which diffuses across cellular membranes, including the blood brain barrier. Used in regional cerebral blood flow imaging. Prepn: L. R. Canning et al., EP 194843; eidem, US 4789736 (1986, 1988 both to Amersham). Prepn and ra-diopharmacology of 99mTc complex: D. P. Nowotnik et al., Nucl. Med. Commun. 6, 499 (1985); R. D. Neirinckx et al., J. Nucl. Med. 28, 191 (1987). Clinical comparison of isomers: P. F. Sharp et al., ibid. 27, 171 (1986). Biodistribution in humans: K. Nakamura et al., Eur. J. Nucl. Med. 15, 100 (1989). Clinical evaluation in single photon emission tomography (SPECT) of meningiomas: S. Nakano et al., J. Nucl. Med. 30, 1101 (1989). 99mTc radiolabeling of human platelets: H. J. Danpure, S. Osman, Nucl. Med. Commun. 9, 267 (1988); of human leukocytes: H. J. Danpure et al., ibid. 465. Clinical study of labeled leukocytes for imaging inflammatory lesions: J. H. Reynolds, Clin. Radiol. 42, 195 (1990). Series of articles on basic and clinical studies: J. Cereb. Blood Flow Metab. 8, S1-S126 (1988).
Properties: Crystals from ethyl acetate, mp 128-130°.
Melting point: mp 128-130°
Therap-Cat: 99mTc complex as diagnostic aid (radioactive imaging agent).