CAS No 105219-56-5 , 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)- Search by region : China

Name: 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-
Synonyms: 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-; WEB-2086; Apafanto;Apafant; WEB 2086BS; Apafantum [INN-Latin]; Apafantum; Apafanto [INN-Spanish]; Web 2086; triazolodiazepine;
CAS Registry Number:105219-56-5
Flash Point: 389.4°C
Boiling Point: 720.2°Cat760mmHg
Density: 1.48
Refractive index: 1.733
Flash Point: 389.4°C
Molecular Weight: 455.96038
InchiKey: JGPJQFOROWSRRS-UHFFFAOYSA-N
InChI: InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-
12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,
1H3
Molecular Formula: C₂₂H₂₂ClN₅O₂S
Molecular Structure:

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105219-56-5 WEB 2086; 4-[3-[4[(2-CHLOROPHENYL)-9-METHYL-6H-THIENO[3,2-F][1,2,4 ]TRIAZOLO[4,3-A]DIAZEPIN-2-YL]-1-OXOPROPYL]MORPHOLINE

Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
Fax: +86 25 8345-3275
Address: Rm.902 Longyin Plaza,
No. 217 Zhongshan Rd.
(N)Nanjing 210009,China null,nullChina

105219-56-5 APAFANT

HANGZHOU ONICON CHEMICAL CO.,LTD [Manufacturer]
Tel: +86-571-85054016/ +86-571-85104679
Fax: +86-571-85054082
Address: HANGZHOU ONICON CHEMICAL CO.,LTD
303-306 Hangzhou yiyao Building,
No.439 Zhongshan North Rd.
Hangzhou China
Phone : +86-571-85054016
Fax: +86-571-85054082
E-Mail1: cjw9999@163.com null,nullChina

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References of 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-

Title: Apafant
CAS Registry Number: 105219-56-5
CAS Name: 4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]morpholine
Synonyms: 3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone
Manufacturers' Codes: WEB-2086
Molecular Formula: C22H22ClN5O2S
Molecular Weight: 455.96
Percent Composition: C 57.95%, H 4.86%, Cl 7.78%, N 15.36%, O 7.02%, S 7.03%
Literature References: Platelet activating factor (PAF) antagonist. Prepn: K. H. Weber et al, DE 3502392; eidem, US 5082839 (1986, 1992 both to Boehringer, Ing.). Pharmacology: J. Casals-Stenzel et al., J. Pharmacol. Exp. Ther. 241, 974 (1987). Clinical pharmacology, pharmacokinetics: H. M. Brecht et al., Arzneim.-Forsch. 41, 51 (1991). Clinical effect vs PAF-induced bronchoconstriction: W. S. Adamus et al., Clin. Pharmacol. Ther. 47, 456 (1990).
Properties: Viscous, almost colorless oil. LD50 in mice (mg/kg): 540 i.v.; 4600 orally (Casals-Stenzel).
Toxicity data: LD50 in mice (mg/kg): 540 i.v.; 4600 orally (Casals-Stenzel)
Use: Tool to evaluate the role of PAF in exptl models of human disease.