Title: Atipamezole
CAS Registry Number: 104054-27-5
CAS Name: 4-(2-Ethyl-2,3-dihydro-1
H-inden-2-yl)-1
H-imidazole
Synonyms: 4(5)-(2-ethyl-2-indanyl)imidazole
Molecular Formula: C14H16N2
Molecular Weight: 212.29
Percent Composition: C 79.21%, H 7.60%, N 13.20%
Literature References: Specific a2-adrenoceptor antagonist. Prepn: A. J. Karjalainen
et al., EP 183492;
eidem, US 4689339 (1986, 1987 both to Farmos). Behavioral and neurochemical effects: H. Scheinin
et al., Eur. J. Pharmacol. 151, 35 (1988). Pharmacodynamics and pharmacokinetics: X. Fargetton, T. V?h?-Vahe,
Tijdschr. Diergeneeskd 114, Suppl. 1, 91S (1989). Binding study in comparison with yohimbine,
q.v.: R. Virtanen
et al., Arch. Int. Pharmacodyn. 297, 190 (1989). Attenuation of ethanol effects in mice: M. J. Durcan
et al., Alcohol 6, 189 (1989). Preliminary report as detomidine,
q.v., antagonist in horses: L. Nilsfors, C. Kvart,
Acta Vet. Scand. 82, 121 (1986). Use as medetomidine,
q.v., antagonist in zoo animals: H. Jalanka,
ibid. 85, 193 (1989).
Derivative Type: Hydrochloride
CAS Registry Number: 104075-48-1
Manufacturers' Codes: MPV-1248
Trademarks: Antisedan (Pfizer)
Molecular Formula: C14H16N2.HCl
Molecular Weight: 248.75
Percent Composition: C 67.60%, H 6.89%, N 11.26%, Cl 14.25%
Properties: Crystals from dry HCl in ethyl acetate, mp 211-215°. LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin).
Melting point: mp 211-215°
Toxicity data: LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin)
Therap-Cat-Vet: Antidote to a2-adrenoceptor induced sedation.