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CAS No 104054-27-5 , 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole

  • Name: 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole
  • Synonyms: MPV 1248; Atipamezol [Spanish]; 104054-27-5; MPV-1248;5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole; Atipamezolum [Latin]; 4-(2-ethyl-2,3-dihydro-1h-inden-2-yl)-1h-imidazole;Antisedan;
  • CAS Registry Number:
  • Density: 1.115 g/cm3
  • Refractive index: 1.594
  • Molecular Weight: 212.29024
  • InchiKey: HSWPZIDYAHLZDD-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,
    9-10H,2,7-8H2,1H3,(H,15,16)
  • Molecular Formula: C14H16N2
  • Molecular Structure:CAS No:104054-27-5 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole

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104054-27-5 Atipamezole

  • China Trust&We Co., Ltd. [Manufacturer]
  • Tel: +86-21-61044582
  • Fax: +86-21-61044583
  • Address: 1-102,No.11,Dongjiaominxiang Alley,
    Dongcheng District,
    Beijing 100005,China null,nullChina
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104054-27-5 1H-Imidazole,5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-

  • China Shanghai chemrole co.,ltd [Manufacturers]
  • Tel: 021-50278900
  • Fax: 021-50278968
  • Address: No.6,bisheng road ,shanghai ,china null,ShanghaiChina
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104054-27-5 Atipamezole

  • China Watson International Ltd. null
  • Tel: +86-(512)-55117610
  • Fax: +86-(512)-55117630
  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, null,nullChina
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104054-27-5 Atipamezole

  • China Xilin Chemical Group Co., Ltd null
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, null,nullChina
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104054-27-5 1H-Imidazole,5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-

  • China Hangzhou APIChem Technology Co., Ltd. [Manufacturers]
  • Tel: +86-571-56059907
  • Fax: +86-571-56059907
  • Address: Hangzhou E&T Development Zone, Hangzhou, Zhejiang, 310018, China Hangzhou,ZhejiangChina
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104054-27-5 ATIPAMEZOLE

  • China Suzhou Yield Pharma Co., Ltd [Manufacturer]
  • Tel: +86-25-85307283
  • Fax: +86-25-85307283
  • Address: 20 Fengji Road,
    Yuhua Economic Development Zone,
    Nanjing, Jiangsu, P. R. China
    Zip Code: 210039 null,nullChina
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References of 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole
Title: Atipamezole
CAS Registry Number: 104054-27-5
CAS Name: 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole
Synonyms: 4(5)-(2-ethyl-2-indanyl)imidazole
Molecular Formula: C14H16N2
Molecular Weight: 212.29
Percent Composition: C 79.21%, H 7.60%, N 13.20%
Literature References: Specific a2-adrenoceptor antagonist. Prepn: A. J. Karjalainen et al., EP 183492; eidem, US 4689339 (1986, 1987 both to Farmos). Behavioral and neurochemical effects: H. Scheinin et al., Eur. J. Pharmacol. 151, 35 (1988). Pharmacodynamics and pharmacokinetics: X. Fargetton, T. V?h?-Vahe, Tijdschr. Diergeneeskd 114, Suppl. 1, 91S (1989). Binding study in comparison with yohimbine, q.v.: R. Virtanen et al., Arch. Int. Pharmacodyn. 297, 190 (1989). Attenuation of ethanol effects in mice: M. J. Durcan et al., Alcohol 6, 189 (1989). Preliminary report as detomidine, q.v., antagonist in horses: L. Nilsfors, C. Kvart, Acta Vet. Scand. 82, 121 (1986). Use as medetomidine, q.v., antagonist in zoo animals: H. Jalanka, ibid. 85, 193 (1989).
 
Derivative Type: Hydrochloride
CAS Registry Number: 104075-48-1
Manufacturers' Codes: MPV-1248
Trademarks: Antisedan (Pfizer)
Molecular Formula: C14H16N2.HCl
Molecular Weight: 248.75
Percent Composition: C 67.60%, H 6.89%, N 11.26%, Cl 14.25%
Properties: Crystals from dry HCl in ethyl acetate, mp 211-215°. LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin).
Melting point: mp 211-215°
Toxicity data: LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin)
 
Therap-Cat-Vet: Antidote to a2-adrenoceptor induced sedation.