Home > Name List By other > (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS, 7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6, 7-hexahydro-1H-inden-4-y...

CAS No 103909-75-7 , (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,
7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,
7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,
3-diol

  • Name: (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,
    7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,
    7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,
    3-diol
  • Synonyms: (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,
    7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,
    7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,
    3-diol; 103909-75-7; Sch-209579; Sch 209579; MC 1275; 1,25-Dihydroxy-22-oxavitamin D3; 22-Oxacalcitriol;Prezios; 22-Oxa-1,25-dihydroxyvitamin D3;
  • CAS Registry Number:
  • Flash Point: 305.4 °C
  • Boiling Point: 581.4 °C at 760mmHg
  • Density: 1.09 g/cm3
  • Refractive index: 1.549
  • Flash Point: 305.4 °C
  • Molecular Weight: 418.60928
  • InchiKey: DTXXSJZBSTYZKE-ZDQKKZTESA-N
  • InChI: InChI=1S/C26H42O4/c1-17-20(15-21(27)16-24(17)28)9-8-19-7-6-12-26(5)22
    (10-11-23(19)26)18(2)30-14-13-25(3,4)29/h8-9,18,21-24,27-29H,1,6-7,
    10-16H2,2-5H3/b19-8+,20-9-/t18-,21+,22+,23-,24-,26+/m0/s1
  • Molecular Formula: C26H42O4
  • Molecular Structure:CAS No:103909-75-7 (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,<br />7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,<br />7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,<br />3-diol

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References of (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,
7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,
7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,
3-diol
Title: Maxacalcitol
CAS Registry Number: 103909-75-7
CAS Name: (1R,3S,5Z)-4-Methylene-5-[(2E)-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Synonyms: (+)-(5Z,7E,20S)-20a-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10(19)-trien-1a,3b-diol; 1a,25-dihydroxy-22-oxavitamin D3; 22-oxa-1a,25-dihydroxyvitamin D3; 22-oxacalcitriol; 22-oxa-1,25(OH)2D3
Manufacturers' Codes: MC-1275; Sch-209579
Trademarks: Oxarol (Chugai); Prezios (Chugai)
Molecular Formula: C26H42O4
Molecular Weight: 418.61
Percent Composition: C 74.60%, H 10.11%, O 15.29%
Literature References: Noncalcemic analog of vitamin D. Prepn: N. Kubodera et al., EP 184112; eidem, US 4891364 (1986, 1990 both to Chugai); E. Murayama et al., Chem. Pharm. Bull. 34, 4410 (1986). Industrial synthesis: H. Shimizu et al., Org. Process Res. Dev. 9, 278 (2005). Pharmacology: A. J. Brown et al., J. Clin. Invest. 84, 728 (1989). Immunomodulatory effects: M. Komine et al., Arch. Dermatol. Res. 291, 500 (1999). Metabolism study: M. Ishigai et al., J. Steroid Biochem. Mol. Biol. 66, 281 (1998). LC-MS determn in serum: idem et al., J. Chromatogr. B 706, 261 (1998). Clinical evaluation in psoriasis: J. Barker et al., Br. J. Dermatol. 141, 274 (1999); in secondary hyperparathyroidism: Y. Tsukamoto et al., Am. J. Kidney Dis. 35, 458 (2000).
Properties: Colorless crystals from hexane + ethyl acetate, mp 122°. [a]D20 +49.4° (c = l.00 in ethanol). uv max (ethanol): 263 nm.
Melting point: mp 122°
Optical Rotation: [a]D20 +49.4° (c = l.00 in ethanol)
Absorption maximum: uv max (ethanol): 263 nm
Therap-Cat: Antihyperparathyroid; antipsoriatic.
Keywords: Antipsoriatic; Antihyperparathyroid.