Title: Vapreotide
CAS Registry Number: 103222-11-3
CAS Name: D-Phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-tryptophanamide cyclic (2?7)-disulfide
Manufacturers' Codes: BMY-41606; RC-160
Trademarks: Octastatin (Debiopharm)
Molecular Formula: C57H70N12O9S2
Molecular Weight: 1131.37
Percent Composition: C 60.51%, H 6.24%, N 14.86%, O 12.73%, S 5.67%
Literature References: Octapeptide somatostatin analog. Prepn: A. V. Schally, R. Z. Cai,
EP 203031 (1986 to Tulane);
eidem,
US 4650787 (1987). Inhibition of growth hormone, insulin and glucagon release: T. Karashima
et al., Life Sci. 41, 1011 (1987); on pancreatic secretion: S. J. Konturek
et al., Proc. Soc. Exp. Biol. Med. 187, 241 (1988). RIA determn in serum: M. Mason-Garcia
et al., Proc. Natl. Acad. Sci. USA 85, 5688 (1988). Clinical pharmacology: M. A. Ritz
et al., Br. J. Clin. Pharmacol. 47, 195 (1999). Clinical trial for variceal bleeding in cirrhosis: P. Calès
et al., N. Engl. J. Med. 344, 23 (2001).
Therap-Cat: Hemostatic.
Keywords: Hemostatic; Somatostatin Analog.
