Home > Name List By 4 > 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

CAS No 102676-47-1 , 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

  • Name: 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
  • Synonyms: CGS-16949A;4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile; 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile; 102676-47-1; Fadrozol [INN-Spanish]; Fadrozole [INN];
  • CAS Registry Number:
  • Transport: 3439
  • Melting Point: 0°C
  • Flash Point: 245.1°C
  • Boiling Point: 0°C
  • Density: 1.2g/cm3
  • Refractive index: 1.661
  • Safety Statements:
    Risk Statements 20/21/22
    Safety Statements 22-24/25
    RIDADR 3439
  • Flash Point: 245.1°C
  • Molecular Weight: 223.27312
  • InchiKey: CLPFFLWZZBQMAO-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/
    h4-7,9-10,14H,1-3H2
  • Risk Statements: 20/21/22
  • Molecular Formula: C14H13N3
  • Molecular Structure:CAS No:102676-47-1 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

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References of 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
Title: Fadrozole
CAS Registry Number: 102676-47-1
CAS Name: 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
Synonyms: 5-p-cyanophenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine
Molecular Formula: C14H13N3
Molecular Weight: 223.27
Percent Composition: C 75.31%, H 5.87%, N 18.82%
Literature References: Aromatase inhibitor. Prepn: L. J. Browne, EP 165904; idem, US 4617307 (1985, 1986 both to Ciba-Geigy); L. J. Browne et al., J. Med. Chem. 34, 725 (1991). Effects on estrogen biosynthesis: R. E. Steele et al., Steroids 50, 147 (1987). Pharmacology: K. Schieweck et al., Cancer Res. 48, 834 (1988). GC/MS determn in plasma and urine: R. Ackermann, G. Kaiser, Biomed. Environ. Mass Spectrom. 18, 558 (1989). Pharmacokinetics: G. M. Kochak et al., J. Clin. Endocrinol. Metab. 71, 1349 (1990). Clinical evaluation in metastatic breast cancer: J. I. Raats et al., J. Clin. Oncol. 10, 111 (1992).
Properties: mp 117-118°.
Melting point: mp 117-118°
 
Derivative Type: Hydrochloride
CAS Registry Number: 102676-31-3
Manufacturers' Codes: CGS-16949A
Trademarks: Afema (Novartis)
Molecular Formula: C14H13N3.HCl
Molecular Weight: 259.73
Percent Composition: C 64.74%, H 5.43%, N 16.18%, Cl 13.65%
Properties: Crystals from 2-propanol, mp 231-233°. Sol in water.
Melting point: mp 231-233°
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic (Hormonal); Aromatase Inhibitors; Aromatase Inhibitors.