Home > Name List By 5 > 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3...

CAS No 100427-26-7 , 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

  • Name: 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl
    2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Synonyms: STK639861; Lercanil (TN); UNII-V7XTJ4R0BH; Lercanidipine (INN); 100427-26-7;Lercanidipine [INN];5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl
    2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; AC1Q1ZXR; masnidipine;
  • CAS Registry Number:
  • Melting Point: 118-120 ºC
  • Density: 1.177 g/cm3
  • Refractive index: 1.579
  • Molecular Weight: 611.72724
  • InchiKey: ZDXUKAKRHYTAKV-UHFFFAOYSA-N
  • InChI: InChI=1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)
    43)32(25(2)37-24)35(41)45-36(3,
    4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,
    33,37H,20-21,23H2,1-6H3
  • Risk Statements: T
  • Molecular Formula: C36H41N3O6
  • Molecular Structure:CAS No:100427-26-7 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl<br />2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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References of 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Title: Lercanidipine
CAS Registry Number: 100427-26-7
CAS Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester
Synonyms: methyl 1,1,N-trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate; methyl 1,1-dimethyl-2-[N-(3,3-diphenylpropyl)-N-methylamino]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; masnidipine
Molecular Formula: C36H41N3O6
Molecular Weight: 611.73
Percent Composition: C 70.68%, H 6.76%, N 6.87%, O 15.69%
Literature References: Dihydropyridine calcium channel blocker. Prepn: D. Nardi et al., EP 153016; eidem, US 4705797 (1985, 1987 both to Recordati). Pharmacology: G. Bianchi et al., Pharmacol. Res. 21, 193 (1989). Clinical evaluation in hypertension: E. Rimoldi et al., Acta Ther. 20, 23 (1994).
 
Derivative Type: Hydrochloride
CAS Registry Number: 132866-11-6
Manufacturers' Codes: Rec-15-2375; R-75
Trademarks: Lerdip (Recordati); Zanidip (Napp)
Molecular Formula: C36H41N3O6.HCl
Molecular Weight: 648.19
Percent Composition: C 66.71%, H 6.53%, N 6.48%, O 14.81%, Cl 5.47%
Properties: Prepd as the hemihydrate, mp 119-123°. LD50 in mice (mg/kg): 83 i.p.; 657 orally (Nardi).
Melting point: mp 119-123°
Toxicity data: LD50 in mice (mg/kg): 83 i.p.; 657 orally (Nardi)
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives.