Natural Sex Hormone Powder Estradiol valerate CAS : 979-32-8

Natural Sex Hormone Powder Estradiol valerate CAS : 979-32-8
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Name: Estradiol valerate
CAS:979-32-8
Synonyms:Estradiol valerate; Oestradiol Valerate; estradiol-17-valerate; 1,3,5(10)-estratriene-3,17b-diol 17-pentanote; Estradiol Valeate; 3-hydroxyestra-1,3,5(10)-trien-17-yl pentanoate; (17beta)-3-hydroxyestra-1,3,5(10)-trien-17-yl pentanoate; (8xi,9xi,14xi,17beta)-3-hydroxyestra-1,3,5(10)-trien-17-yl pentanoate
Molecular Formula C23H32O3
Molecular Weight 356.50
EINECS 213-559-2
Melting point 144 o C
Boiling point:486.2°C at 760 mmHg
Flash point:191.1°C
Refractive index:1.567
Appearance: White or almost-white,crystalline powder or colorless crystals
Density:1.13g/cm3
Vapour Pressure:4.47E-10mmHg at 25°C


Description:
Estrogens have been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause, especially in women who receive estrogen-only hormone therapy. Contact your doctor immediately if you experience any unusual vaginal bleeding. Estrogens may also increase the risk of cancer of the ovary or breast. Estrogen-containing products should not be used to prevent heart disease. Estrogen given with another hormone (progestin) for replacement therapy can infrequently cause heart disease (eg, heart attacks), stroke, serious blood clots in the legs or lungs (pulmonary embolism/deep vein thrombosis), dementia, and cancer of the breast. These risks appear to depend on the length of time estradiol valerate is used and the amount of estrogen per dose. Therefore, estradiol valerate should be used for the shortest possible length of time at the lowest effective dose so that you obtain the benefits and minimize the chance of serious side effects from long-term treatment. Consult your doctor or pharmacist for details.

Apllication:
Treating certain symptoms of menopause (eg, hot flashes, vaginal itching, burning, or dryness). It is used to treat low levels of estrogen caused by certain conditions. It may be used to treat certain types of prostate cancer (advanced androgen-dependent). It may also be used for other conditions as determined by your doctor.

Estradiol valerate is a female estrogen hormone. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen.It works for advanced prostate cancer by antagonizing male hormones.

COA:
Tests Specifications Results
Description White Crystalline powder White Crystalline powder
Identification IR Positive
Melting point Melting range between 143～150℃ 149.5??
Specific rotation Specific rotation +41??to +47?? +46.5??
Limit of Estradiol ?ü1.0% 0.4%
Ordinary impurities ?ü2.0% Passed
Water ?ü0.1% 0.08%
Free Acid ?ü0.5% 0.35%
Assay 98.0～102.0% (on the dried basis) 99.8%

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