Healthy 99% Pharmaceutical Intermediates Orlistat for Weight Loss 96829-58-2
More details about Orlistat:
CAS: 96829-58-2
MF: C29H53NO5
MW: 495.73
Assay: 99%
Appearance: White powder
Package: foil bag
Orlistat blocks some of the fat that you eat, keeping it from being absorbed by your body.
Orlistat is used to aid in weight loss, or to help reduce the risk of regaining weight already lost. This medicine must be used together with a reduced-calorie diet.
Orlistat is for use only in adults.It is dangerous to purchase orlistat on the Internet or from vendors
outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of "alli" purchased on the Internet have been found to contain sibutramine (Meridia), a prescription weight loss medication that can have dangerous side effects in certain people. For more information, contact the U.S. Food and Drug Administration (FDA) or visit .
Orlistat (also known as tetrahydrolipstatin) is a drug designed to treat obesity. It is marketed as a prescription drug under the trade name Xenical by Roche in most countries, and is sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug.
Use:
(1) Orlistat is used for the treatment of obesity. The amount of weight loss achieved with orlistat varies. In one-year clinical trials, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat. Between 16.4% and 24.8% achieved at least a 10% decrease in body fat. After orlistat was stopped, a significant number of subjects regained weight—up to 35% of the weight they had lost.
(2) The incidence of type 2 diabetes in an obese population over four years is decreased with orlistat (6.2%) compared to placebo (9.0%). Long-term use of orlistat also leads to a modest reduction in blood pressure (mean reductions of 2.5 and 1.9 mmHg in systolic and diastolic blood pressure respectively).
The effectiveness of orlistat in promoting weight loss is definite, though modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2-3 kilograms (4.4-6.6 lb) more than those not taking the drug over the course of a year.Orlistat also modestly reduces blood pressure, and appears to prevent the onset of type 2 diabetes, whether due to weight loss itself or to other effects; in a large randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly 40% in obese people.
Orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). These decrease with time, however, and are the most frequently reported adverse effects of the drug. In the United States and the European Union, orlistat is available for sale without a prescription. Over-the-counter approval was controversial in the United States, with consumer advocacy group Public Citizen repeatedly opposing it on safety and efficacy grounds. Generic formulations of orlistat are available in some countries. A prescription is needed for use in Australia.
Certificate Of Analysis (COA)
Items
Specification Items
Appearance
white or almost white crystalline powder,smell less
Melting Point
42.0~46.0°C
Specific Rotation
-31°~-39°(CHCl3,C=1)
Identification
The result of HPLC is consisitent to the reference one. The result of IR is consisitent to the reference one.
Related Substances
≤ 0.5%
Total impurity
≤ 1.0%
Single impurity
≤ 0.1%
n-Hexane
≤ 290ppm
Isopropyl ether
≤ 5000ppm
Residual on Ignition
≤0.1%
Sulphate
≤ 0.05%
Heavy Metal
≤ 20ppm
Purity
≤ 99.0% ~ 99.9%
Healthy 99% Pharmaceutical Intermediates Orlistat for Weight Loss 96829-58-2
Competitive Advantage:
1, High quality with competitive price
1) Standard: Enterprise Standard .
2) All Purity≥99%.
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment. Tracking number available.
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99%.
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.
4. Good after-sales service.
Tell the package update ASAP, and will try best solve when customer encountered various problems.
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