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PF-562271 (besylate)

  • Purity: >98%
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:PF-562271 (besylate)
  • CAS No: 939791-38-5

Details

PF-562271 (besylate)PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

IC50 value: 1.5 nM(FAK); 14 nM(Pyk2) [1]

Target: PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region.

Target:Proteasome

Product Links:http://www.medchemexpress.cn/pf-562271-besylate.html

Permanent link:http://www.medchemexpress.com/pf-562271-besylate.html

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