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Navitoclax

  • CAS No.: 923564-51-6
  • Purity: >98%
  • Weight: 974.61
  • Formula: C47H55ClF3N5O6S3
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:Navitoclax
  • CAS No: 923564-51-6
  • Weight: 974.61
  • Formula: C47H55ClF3N5O6S3
  • Melting Point: 114-116 °C
  • Density: 1.41 g/cm3

Details

NavitoclaxABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM.

IC50 Value: ≤ 0.5 nM(Ki for Bcl-xL); ≤1 nM(Ki for Bcl-2); ≤1 nM(Ki for Bcl-w)

Target: Bcl-2 Family

in vitro: ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively.

Target:Bcl-2 Family

Product Links:http://www.medchemexpress.cn/navitoclax.html

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