CAS NO:9005-65-6 Tween 80
IUPAC name:Polyoxyethylene (20) sorbitan monooleate
Other names:Alkest TW 80,Tween 80
CAS Registry Number:9005-65-6
Chemical formula:C64H124O26
Molar mass:1310 g/mol
Appearance:Amber colored viscous liquid
Density:1.06-1.09 g/mL, oily liquid
Boiling point: > 100°C
Solubility in water:Very soluble
Solubility in other solvents:soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, toluene
Viscosity:300-500 centistokes (@25°C)
Uses
Food use
Polysorbate 80 is used as an emulsifier in foods.
For example in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting. Adding this substance prevents milk proteins from completely coating the fat droplets. This allows them to join together in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.
Health and beauty use
Polysorbate 80 is also used as a surfactant in soaps and cosmetics, or a solubilizer such as in a mouthwash. The cosmetic grade of polysorbate 80 may have more impurities than the food grade.
Medical use
Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the manufacture of the popular antiarrhythmic amiodarone. It is also used as an excipient in some European and Canadian influenza vaccines.Influenza vaccines contain 25 μg of polysorbate 80 per dose. It is also used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth. It is also used as an emulsifier in the estrogen-regulating drug Estrasorb.
Consumption and potential effects
In Europe and America, people eat about 100 mg of polysorbate 80 in foods per day on average. Polysorbate 80 is not carcinogenic. Rats fed with diets containing up to 5% polysorbate 80 by volume for 12 weeks showed no toxic effects. A 1997 study on two rats looked at the effect of consuming three doses by body weight of 0.5%/day on the sex organs of female rats and saw no abnormal changes in uterine weight. In general, polysorbate 80 is safe and well tolerated, notwithstanding the items listed below.
Crohn's disease
A small number of people may be sensitive to polysorbate 80, and it may be harmful to people with Crohn's disease.
Lowered body weight of offspring
A 2008 animal study concluded no observable adverse effects were seen at doses per body weight up to 1.85 ml/kg·day, which is equivalent to a 70 kg person consuming about 140 g of this substance per day for 21 days. However, administration of 16.783 ml/kg·day to pregnant rats lowered body weight in male and female offspring. This is equivalent to a person consuming about 1.3 kg of polysorbate 80 per day for 21 days.
Decreased fertility
A 1956 study saw no effect on reproduction in rats during their lifetime at up to 5% of their diet being polysorbate 80. Reproduction decreased at 20% of their diet. A 1993 study raised concerns that polysorbate 80 might decrease fertility in rats.
Impact on mouse gut microbiota
Relatively low concentrations of two commonly used emulsifiers, namely carboxymethylcellulose and polysorbate-80, induced low-grade inflammation and obesity/metabolic syndrome in wild-type hosts and promoted robust colitis in mice predisposed to this disorder. Use of germ-free mice and fecal transplants indicated that such changes in microbiota were necessary and sufficient for both low-grade inflammation and metabolic syndrome.
Laboratory use
Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules). When added to a mixture of polysorbate 80 and phenol red, they cause the solution to change colour, so this is used as a test to identify the phenotype of a strain or isolate.
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