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Hot sell Toremifene Citrate wirh attractive price/ frank@chembj.com

  • CAS No.: 89778-27-8
  • Min quantity: 1000 Kilograms
  • Price: USD 500~900/Kilograms
  • Weight: 598.08314
  • Place of Orign: Zhongshan,South Australia,Australia
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  • Product Name.: Hot sell Toremifene Citrate wirh attractive price/ frank@chembj.com
  • CAS No: 89778-27-8
  • Weight: 598.08314
  • Formula: C32H36ClNO8
  • Melting Point: 158-164 ºC
  • Boiling Point: 535.1 ºC at 760 mmHg
  • Density: 1.045g/cm3

Details

Toremifene Citrate

Synonyms: FC 1157a; Fareston; NK 622; NSC 613680
CAS: 89778-27-8
Molecular Formula: C26H28ClNO·C6H8O7
Melting Point: 158-164 oC
Molecular Weight: 598.09
Boiling Point: 535.1 oC at 760 mmHg
Density: 1.045g/cm3
Refractive index: 1,416-1,418
Appearance: White or almost white powder
use:As an anticancer drug, it is suitable for the treatment of postmenopausal women with estrogen receptor positive / or unknown metastatic breast cancer.

Toremifene citrate Description:
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a 'fake' Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there.
Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially 'tricks' the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.
Toremifene is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular). This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus, it will act as an Estrogen within the liver. This can have beneficial impacts especially during an anabolic steroid cycle, such as improving and shifting cholesterol levels into a more favorable range.
Hot sell Toremifene Citrate wirh attractive price/ frank@chembj.com

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