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CAS No:86639-52-3 7-Ethyl-10-hydroxycamptothecin
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SN-38

  • CAS No.: 86639-52-3
  • Purity: >98%
  • Weight: 392.40
  • Formula: C22H20N2O5
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:SN-38
  • CAS No: 86639-52-3
  • Weight: 392.40
  • Formula: C22H20N2O5
  • Melting Point: 217 °C
  • Boiling Point: 810.3 °C at 760 mmHg
  • Density: 1.51 g/cm3

Details

SN-38SN-38(NK-012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

IC50 Value:

Target: topoisomerase I

in vitro: Among TIs, SN-38 had the highest cytotoxicity towards OSCC cell lines, with a tumor specificity index of 1321 compared to mesenchymal cells and 22 compared with epithelial cells.

Target:Glucocorticoid Receptor

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CAS No:86639-52-3 7-Ethyl-10-hydroxycamptothecin

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