ICG-001CG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
IC50 value: 3 uM
Target: Wnt
in vitro: ICG-001 has no effect on the related reporter construct, FOPFLASH, which contains mutated TCF sites.
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