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17-Hydroxyprogesterone service01@chembj.com

  • CAS No.: 68-96-2
  • Purity: 99%
  • Min quantity: 50000 Kilograms
  • Price: USD 1~2/Kilograms
  • Place of Orign: Zhuhai,Guangdong,China
Ms.June Jin

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Item specifics

  • Product Name.:17-Hydroxyprogesterone service01@chembj.com
  • CAS No: 68-96-2
  • Weight: 330.4611
  • Formula: C21H30O3
  • Melting Point: 276 ºC
  • Boiling Point: 482.9 °C at 760 mmHg
  • Density: 1.15 g/cm3

Details

17-Hydroxyprogesterone
Synonyms:17-Hydroxypregn-4-en-3,20-dione;17-hydroxy-pregn-4-ene-20-dione;17-hydroxypregn-4-ene-3,20-dione;delta(4)-pregnene-17alpha-ol-3,20-dione;gestagenogador;prodix;prodox;(8R,9S,10R,13S,14S,17R)-17-ACETYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
CAS: 68-96-2
MF: C21H30O3
MW: 330.46
EINECS: 200-699-4
Chemical Properties White Solid
Usage Progesteron. It was isolated from adrenal glands.
Usage anticoagulant
Usage 17α-Hydroxy Progesterone is a metabolite of Progesterone. It was isolated from adrenal glands.

Hydroxyprogesterone Usage:?
The 17-hydroxyprogesterone (17-OHP) test is routinely ordered as part of newborn screening in the UnitedStates to detect congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. CAH is a group of inherited disorders caused by specific gene mutations and associated with cortisol-related enzyme deficiencies. About 90% of CAH cases are caused by a mutation in the 21-hydroxylase gene (also called P450c1 or CYP21A2) and may be detected due to the accumulation of 17-OHP in the blood.
?
The 17-OHP test may be used to screen for CAH in older children or adults before symptoms appear or to confirm a CAH diagnosis in people with symptoms.
?
17-OHP testing may produce false-positive test results. If the level is elevated but not so high that it is diagnostic of CAH, other tests may be performed, such as androstenedione and testosterone. An ACTH stimulation test may be also be ordered as a follow-up test (in CAH, ACTH stimulation will markedly increase 17-OHP levels). Molecular genetic testing may be performed to detect CYP21A2 gene mutations thatcan cause the condition. A karyotype test may be ordered as a follow-up test to detect chromosome disorders and to help determine a baby's sex. Electrolytes may be ordered to measure the person's sodium and potassium levels.

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