Molecular formula: C20H30ClN5O3
Molecular weight: 423.9369
Molecular Structure:
Boiling point: 549 ° C at 760 mmHg
Flash point: 285.8 ° C
Vapor pressure: 4.22E-12mmHg at 25°C
Uses: for the treatment of various types of hypertension, high blood pressure.
Appearance: white or off-white crystalline powder.
Introduction:
Urapidil HCl is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist.
Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonistand 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blockingeffect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system [1]. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated viastimulation of serotonin 5HT1A receptors in the central nervous system. Several studies havepy suggested that oral urapidil is effective and well tolerated when used as second-line therapy inpatients with BP inadequately controlled with other agents.
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