VX-680 (Tozasertib, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. Phase 2.
Description: Belnacasan(VX-765) is an orally active, reversible caspase-1 inhibitor. Belnacasan(VX-765) was used for the treatment of inflammatory disorder. it is an orally absorbed prodrug of VRT-043198.