Androstenedione
Another name: 4 - androstenedione; 4 - male (steroid)-ene -3,17 - dione;
CAS No: 63-05-8
Specification: 99%
Heavy :10PPM Rotation +193 ° - +202 °
Loss on drying:0.5%
Impurity :1% steroid hormone
Molecular Formula: C19H26O2
Molecular Weight: 286.41
Characters: near white crystalline powder, soluble in ethanol, insoluble in water
Uses: Simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroids, norethisterone, testosterone propionate in the middle
Body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.
Packing: foil bag/tin
Payment: Bank Transfer, Western Union, Money Gram
Express: EMS, DHL, FedEx, etc(door-to-door)
Delivery: Safe & timely, around 1-3 days after payment
Applications:
4-Androstenedione is the common precursor of male and female sex hormones. Some 4-Androstenedione is also secreted into the plasma, and may be converted in peripheral tissues to testosterone and estrogens.
4-Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion of dehydroepiandrosterone to 4-Androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to 4-androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of 4-androstenedione, whether immediately or one step removed.
The production of adrenal 4-Androstenedione is governed by ACTH, whereas production of gonadal 4-Androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total 4-androstenedione(about 3 mg/day). After menopause, 4-androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. Nevertheless, 4-androstenedione is the principal steroid produced by the postmenopausal ovary.
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