Laropiprant(Cardaptive; MK 0524) is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 muM for the DP1 and DP2 receptors, respectively. Laropiprant(Cardaptive; MK 0524) inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.
Hangzhou LedunTechnology provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use. We have an enthusiastic, energetic and friendly Technical and Customer Support team with years of experience in the Life Science industry. LedunTechnology lay great attention on the purity, stability and activity of the compounds, esp. You can rely on us to be a competent and trustworthy par...
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Basic Information
Business Type: Manufacturer
Product/Service (We Buy): 51 - 100 People
Ownership Type: Corporation/Limited Liability Company
Registered Capital: Below US$100 Thousand
Year Established: 2011
Number of Employees: 51 - 100 People
Trade & Market
Main Markets: South America,Eastern Asia,Eastern Europe
QA/QC: In House
Number of Production Lines: 3
Number of R&D Staff: 96
Number of QC Staff: 5 - 10 People
Total Annual Sales Volume: US$50 Million - US$100 Million
China
