17 alpha-Estradiol; Alpha-estradiol 17A-estradiol; CAS 57-91-0 For Anti-aging

17 alpha-Estradiol; Alpha-estradiol 17A-estradiol; CAS 57-91-0 For Anti-aging
Specifications
17 alpha-Estradiol
Hormones
For anti-aging face cream
17 alpha-Estradiol
Synonyms: Alpha-estradiol; 17A-estradiol
CAS: 57-91-0
EINECS: 200-354-8
Molecular Formula: C18H24O2
Molecular Weight: 272.39
Molecular Structurer:
Appearance :hite or off-white crystalline powder
Assay :99%min.
Melting range:216-224 oC
Specific rotation:+52o to +60o
Loss on drying :3.5%MAX
Monor impurity :0.2%MAX
Total impurities:1.0% max
17 alpha-Estradiol is a kind of estrogen that can promote and regulate the female sex organs and sexual characteristics of normal development. To promote development of ductal hyperplasia, but in larger doses, can inhibit the release of anterior pituitary prolactin, and reduction of milk secretion.
Cosmeceutical use: Anti-aging face creams.
Storage: Stored in cool place, keep container tightly closed in a dry and well-ventilated place.
Shelf life: 2 years in unopened container.

Description:
Estradiol (called α - estradiol or 17α - estradiol) for human breast cancer cells in tissue culture biologically active estrogen. Not part of the 17- and selective estrogen receptor (ER-X) traditional hormone / receptor of the endocrine system, but an important autocrine / paracrine function of the system is part of the growth in the adult brain. In menopause, and neurodegenerative diseases (eg Alzheimer's disease and ischemic stroke) treatment, 17- estradiol may have important implications for hormone replacement therapy thing.

The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after the menopause. Thus, estradiol enhances breast development, and is responsible for changes in the body shape, affecting bones, joints and fat deposition. Fat structure and skin composition are modified by estradiol.

Applications:
This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.
Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment.

COA:
Product name Estradiol
Appearance White crystalline powder
Characteristics White or creamy white, crystalline powder conform
Melting point 176-180 ??C 178~ 179??C
Water ?ü3.5% pass
Assay 97 .0~ 103.0% 99.3%
Loss on drying ?ü0.5% 0.1%
Related substances total impurities ?ü1.0% Pass
any individual impurity ?ü0.5% Pass
Residual solvents ethanol ?ü0.5% Pass


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