BIKUITONG
English Name: PRAZIQUANTEL
Common name: Praziquantel
Chemical name: 2- cyclohexyl formyl -1,2,3,6,7,11b- six hydrogen -4H- pyrazine and [2, 1- alpha] isoquinoline -4- ketone
CAS No: 55268-74-1
Structure type
Molecular formula: C19H24N2O2
Molecular weight: 312.41
The content of 99%
Specifications: 0.2g
Praziquantel trait
Properties: white crystalline powder; bitter taste.
This product is soluble in chloroform, dissolved in ethanol, insoluble in ether or water.
Melting Point: 136 to 141 DEG C.
Pharmacokinetics of praziquantel
The drug was rapidly absorbed after oral administration, more than 80% can be absorbed from the intestine. Peak blood arrive in 1 hours or so, quickly metabolize drugs into the liver, the main form of hydroxy metabolites, only a very small amount of unmetabolized drug enters the systemic circulation. Concentration in blood of portal vein blood drug concentration is more than 10 times higher than the peripheral vein. 15%~20% cerebrospinal fluid concentration of blood drug concentration about medication lactating patients, drug concentration in the milk in the serum of 25% equivalent. Peak plasma after oral administration of 10~15mg/kg was about 1mg/L. Drugs are distributed mainly in the liver, followed by kidney, lung, pancreas, adrenal, pituitary gland, salivary gland, rarely by the placenta, non organ specific accumulation phenomenon. T1/2 is 0.8~1.5 hours, the metabolites of T1/2 for 4~5 hours. The main metabolites excreted by the kidneys to, 72% to 24 hours from 80% to 4 days of discharge.
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