CAS NO:55-06-1
Chemical name:3,3',5-Triiodo-L-thyronine, sodium salt
Molecular formula:C15H12I3NO4
Molecular Weight:650.97
Molecular Structure:
Content:(%):99
Boiling point:205°C
water-solubility:4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
Appearance: White or light yellow powder
Usage: Pharmaceutical intermediates, mix it with PEG 400 and take it orally.
Description:
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
Production of T3 and its prohormone thyroxine (T4) is activated by thyroid-stimulating hormone (TSH), which is released from the pituitary gland. This pathway is regulated via a closed-loop feedback process: Elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the pituitary gland. As concentrations of these hormones decrease, the pituitary gland increases production of TSH, and by these processes, a feedback control system is set up to regulate the amount of thyroid hormones that are in the bloodstream.
As the true hormone, the effects of T3 on target tissues are roughly four times more potent than those of T4. Of the thyroid hormone that is produced, just about 20% is T3, whereas 80% is produced as T4. Roughly 85% of the circulating T3 is later formed in the thyroid by removal of the iodine atom from the carbon atom number five of the outer ring of T4. In any case, the concentration of T3 in the human blood plasma is about one-fortieth that of T4. This is observed in fact because of the short half-life of T3, which is only 2.5 days. This compares with the half-life of T4, which is about 6.5 days.
Application:
As for the dosage, one should be very careful since T3 is a very strong and highly effective thyroid hormone. It is extremely impor-tant that one begins with a low dosage, increasing it slowly and evenly over the course of several days. Most athletes begin by tak-ing one 25-mcg tablet per day and increasing this dosage every three to four days by one additional tablet. A dose higher than 100-mcg/ day is not necessary and not advisable. It is not recommended that the daily dose be taken all at once but broken down into three smaller individual doses so that they become more effective. It is also impor-tant that T3 not be taken for more than six weeks. At least two months of abstinence from the drug needs to follow.
Those who take high dosages of T3 over a long period of time are at risk of developing a chronic thyroid insufficiency. As a consequence, the athlete might be forced to take thyroid medication for the rest of his life. It is also important that the dosage is reduced slowly and evenly by taking fewer tablets and -not be ended abruptly. Those who plan to take T3 should first consult a physician in order to be sure that no thyroid hyperfunction exists.
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