Product Details:?
1, CAS NO.:514-61-4
2,Alias:Normethandrolone; Methyloestrenolone; Normethisterone
3, Purity:99%
4, Character: white crystalline powder
5,?Specification:USP/BP
6,Molecular structure:
Description:
?
Norethisterone (or norethindrone) (or 19-nor-17-ethynyltestosterone) is a molecule used in some combined oral contraceptive pills, progestogen only pills and is also available as a stand-alone drug. It is a progestogen and can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with oestrogen), or to postpone a period. It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or pre-surgical gynecologic cases. Norethindrone was the first orally highly active progestin to be synthesized. It was synthesized for the first time by chemists Luis Miramontes, Carl Djerassi, and George Rosenkranz at Syntex in Mexico City in 1951.[1] It was the progestin used in one of the first three oral contraceptives. Its related ester, norethisterone acetate, is used for the same indications.
Applications:?
Norethisterone should be used with caution in: patients who are obese or have a family member who has had a blood clot in their legs or lungs, fibroidsof the womb, raised blood pressure (hypertension), raised blood sugar(diabetes), depression, water retention, migraine, fitting (epilepsy), asthma, heart, liver or kidney problems, varicose veins, smoking, multiple sclerosis,muscle spasm (tetany), gallstones, problems with contact lenses,amenorrhoea (lack of menstrual periods), previous ectopic pregnancy (where the foetus develops outside the womb) and the immune condition systemiclupus erythematosus (also known as SLE).
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It should not be used in: the elderly, children, patients who are allergic to norethisterone or to any of the other ingredients contained in the medicine, pregnancy, patients who have problems with their circulation such asphlebitis or blood clots, patients who have had a heart attack, stroke orangina, patients with yellowing of the skin or whites of the eyes (jaundice) during pregnancy or while taking the pill, patients with severe liver problems, liver tumours, or tumours of the breast, womb or ovaries, patients with irregular or unusual vaginal bleeding of unknown cause, the rare inherited blood condition porphyria or the blood disorder sickle cell anaemia, patients undergoing surgery or patients who have to take bed rest or remain immobile for a long time, patients who have had severe itching or rash caused byHerpes virus during pregnancy, patients with an intolerance to certain sugars.
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Also see list of precautions and interactions
Specifications?:
Analysis Report
Test?Item Standard Test?Results
Appearance White?or?alomost?white?crystalline?powder? white?crystalline?powder
Loss?on?drying <0.5% 0.24%
Optical?rotation +69~+74 73.3
Assay 97--103% 99%
Free?acid 0.5%max 0.21%
Conclusion The?aboye?product?conforms?analysis?standard Conform
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