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Ko 143

  • CAS No.: 461054-93-3
  • Purity: >98%
  • Weight: 469.5732
  • Formula: C26H35N3O5
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:Ko 143
  • CAS No: 461054-93-3
  • Weight: 469.5732
  • Formula: C26H35N3O5
  • Melting Point: 147 ºC
  • Boiling Point: 689.8°C at 760 mmHg
  • Density: 1.24

Details

Ko 143Ko 143 is a potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM), Ko 143 displays > 200-fold selectivity over P-gp and MRP-1 transporters.

IC50 value: 26 nM (EC90) [1]

Target: BCRP

in vitro: Ko143 appears to be the most potent BCRP inhibitor known thus far.

Target:BCRP

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CAS No:461054-93-3 (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester

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