CAS No:4042-36-8 (2R)-5-oxopyrrolidine-2-carboxylic acid

D-Pyroglutamic acid

CAS No.: 4042-36-8
Purity: 98% or order
Min quantity: 1000 Kilograms
Price: USD 70~90/Kilograms
Place of Orign: Changsha,Hunan,China

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Hunan Huateng Pharmaceutical Co. Ltd.
China
Contact:Ms.Chem Peg
Tel:86-0731-82251112
Total Annual Sales Volume:US$10 Million - US$50 Million
Number of Employees:101 - 500 People
Business Type:Manufacturer
Main Markets:North America,Southeast Asia,Mid East,South America,Eastern Asia,Eastern Europe,Oceania,Western Europe

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Product Name.:D-Pyroglutamic acid
CAS No: 4042-36-8
Weight: 129.11398
Formula: C₅H₇NO₃
Melting Point: 155-162 ºC
Boiling Point: 453.1°Cat760mmHg
Density: 1.38g/cm³

Details

Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
Pyroglutamic acid, also known as pidolic acid, exists as two distinct enantiomers:

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D-Pyroglutamic acid

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