GW501516
Synonyms: 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid;Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid;2-(4-((2-(4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid;GW 1516;2-(2-methyl-4-((5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)methylthio)phenoxy)acetic acid;Cardarine;GSK-516
CAS No: 317318-70-0
Molecular Formular: C21H18F3NO3S2
Molecular Weight: 453.498
Appearance: White fine powder
Usage:An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.
[SARMs Series We Supply]
1. Ostarine, MK-2866, Enobosarm ( CAS No.:1202044-20-9/841205-47-8 )
2. Ibutamoren mesylate, MK-677(CAS No.: 159752-10-0 )
3. LGD-4033(CAS No.: 1165910-22-4)
4. Andarine(S4) (CAS No.: 401900-40-1)
5. GW-501516 (CAS No.:317318-70-0)
6. AICAR (CAS No.:2627-69-2)
7. Research chemical:SR9009(CAS No.:1379686-30-2)
[Introduction]
GW501516 (also known as GW-501,516, GW1516, GSK-516 and Endurobol)is a PPARδ receptor. It activates the same pathways activated through exercise, including PPARδ and AMP-activated protein kinase. It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. GW501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone.
[Function]
GW501516 could be used by athletes as an ergogenic performance enhancing drug that was not currently controlled by regulations or detected by standard tests. One of the main researchers from the study on enhanced endurance consequently developed a urine test to detect the drug, and made it available to the International Olympic Committee.
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