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CAS No:301836-41-9 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
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SB-431542

  • CAS No.: 301836-41-9
  • Purity: >98%
  • Weight: 384.38744
  • Formula: C22H16N4O3
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:SB-431542
  • CAS No: 301836-41-9
  • Weight: 384.38744
  • Formula: C22H16N4O3
  • Boiling Point: 662.4°C at 760 mmHg
  • Density: 1.373g/cm3

Details

SB-431542SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.

IC50 value: 94 nM [1]

Target: TGF-βReceptor

in vitro: SB 431542 inhibits the activin type I receptor ALK4 and the nodal type I receptor ALK7, which are responsible for the phosphorylation of Smad2.

Target:Estrogen Receptor_ERR

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CAS No:301836-41-9 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

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