Reparixin

ReparixinReparixin(DF 1681Y) is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation, which has been shown to attenuate inflammatory responses in various injury models.

IC50 Value: 5.6 nM/80 nM (for CXCR1 weight and cells expressing Ile43Val CXCR1 mutant respectively)[1]

Target: CXCR1/2

in vitro: The efficacy of RPX (tested in a wide range of concentrations (1-1000 nM)) was lower in cells expressing Ile43Val CXCR1 mutant (IC50 values of 0.0056 and 0.08 uM for CXCR1 weight and CXCR1 Ile43Val, respectively) [1].

Target:Axl

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