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CAS No:243984-11-4 ethyl<br />(6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohexene-1-carboxylate
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TAK-242

  • CAS No.: 243984-11-4
  • Purity: >98%
  • Weight: 361.816183
  • Formula: C15H17ClFNO4S
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:TAK-242
  • CAS No: 243984-11-4
  • Weight: 361.816183
  • Formula: C15H17ClFNO4S
  • Melting Point: 68-69 ºC
  • Boiling Point: 461.958°C at 760 mmHg
  • Density: 1.39

Details

TAK-242TAK-242 (Resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.

IC50 value: 1.1-11 nM [1]

Target: TLR4

in vitro: In RAW264.7 cells and mouse peritoneal macrophages, TAK-242 suppressed lipopolysaccharide (LPS)-induced production of NO, tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-6, with 50% inhibitory concentration (IC50) of 1.1 to 11 nM.

Target:Others

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Description: Orteronel (TAK-700 R-form) is a naphthylmethylimidazole derivative.Orteronel (TAK-700 R-form) is a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.

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CAS No:243984-11-4 ethyl<br />(6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohexene-1-carboxylate

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