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CAS No:204005-46-9 (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
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SU5416

  • CAS No.: 204005-46-9
  • Purity: >98%
  • Weight: 238.28446
  • Formula: C15H14N2O
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:SU5416
  • CAS No: 204005-46-9
  • Weight: 238.28446
  • Formula: C15H14N2O
  • Boiling Point: 481.4 °Cat760mmHg
  • Density: 1.256 g/cm3

Details

SU5416Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR.

IC50 value: 1.23 uM [1]

Target: VEGFR

in vitro: Semaxanib inhibits VEGF-dependent phosphorylation of the Flk-1 receptor in Flk-1-overexpressing NIH 3T3 cells with IC50 of 1.04 μM.

Target:Antibacterial

Product Links:http://www.medchemexpress.cn/su5416.html

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