Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM. Aliskiren hemifumarate can bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans. More information please visit the website: http://www.creative-enzymes.com/product/Aliskiren-Hemifumarate_2309.html
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