Hot Selling Factory Direct Supply Steroid Hormone Powder Budesonide

Hot Selling Factory Direct Supply Steroid Hormone Powder Budesonide

Product Details:
1,Manufacturer :TOP STEROIDS
2,Molecular Formula:C25H34O6
3,Molecular Weight:430.53
4,Purity:99%
5, Character: White Crystalline Powder
6,Shipment: EMS, DHL, FedEx, TNT

Description:

Budesonide is a glucocorticoid steroid for the treatment of asthma, COPD and non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. In addition, it is used for Crohn's disease (inflammatory bowel disease).
A new extended-release formulation of budesonide called "Uceris" has been recently approved by the United States FDA for ulcerative colitis.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Asthma[edit]Budesonide is nebulized for maintenance and prophylactic treatment of asthma including patients who require oral corticosteroids and those who may benefit from systemic dose reduction.
Crohn's disease[edit]Treatment of active Crohn's disease involving the ileum and/or ascending colon; maintenance of remission (for up to 3 months) of Crohn's disease (mild-to-moderate) involving the ileum and/or ascending colon.
Ulcerative colitis[edit]Budesonide assists in the induction of remission in patients with active ulcerative colitis.
Budesonide:
Controls the rate of protein synthesis.
Depresses the migration of polymorphonuclear leukocytes and fibroblasts.
Reverses capillary permeability and lysosomal stabilization at the cellular level to prevent or control inflammation.
Has a potent glucocorticoid activity and weak mineralocorticoid activity.
Onset of action: Nebulization: 2-8 days; Inhalation: 24 hours
Peak effect: Nebulization: 4-6 weeks; Inhalation: 1-2 weeks
Distribution: 2.2-3.9 L/kg
Protein binding: 85% to 90%
Metabolism: Hepatic via CYP3A4 to two metabolites: 16 alpha-hydroxyprednisolone and 6 beta-hydroxybudesonide; minor activity
Bioavailability: Limited by high first-pass effect; Capsule: 9% to 21%; Nebulization: 6%; Inhalation: 6% to 13%
Half-life elimination: 2-3.6 hours
Time to peak: Capsule: 0.5-10 hours (variable in Crohn's disease); Nebulization: 10-30 minutes; Inhalation: 1-2 hours; Tablet: 7.4-19.2 hours
Excretion: Urine (60%) and feces as metabolites.


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