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CAS No:167869-21-8 2-(2-amino-3-methoxyphenyl)chromen-4-one
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PD98059

  • CAS No.: 167869-21-8
  • Purity: >98%
  • Weight: 267.27932
  • Formula: C16H13NO3
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:PD98059
  • CAS No: 167869-21-8
  • Weight: 267.27932
  • Formula: C16H13NO3
  • Boiling Point: 453.1 °C at 760 mmHg
  • Density: 1.3 g/cm3

Details

PD98059PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2.

IC50 value: 2 uM

Target: MEK

in vitro: PD98059 inhibits either basal MEK1 or a partially activated MEK produced by mutation of serine at residues 218 and 222 to glutamate (MEK-2E) with IC50 of 2 μM.

Target:c-Met_HGFR

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