SCR7SCR7 is a molecule that inhibits joining of DSBs in cell-free repair system; inhibits NHEJ(nonhomologous end-joining) in a Ligase IV-dependent manner within cells, and activates the intrinsic apoptotic pathway.
IC50 value: ~40 nM in Hela and A549 cell [1]
Target: Ligase IV inhibitor; NHEJ inhibitor
in vitro: SCR7 does not induce DSBs directly to the genome and is Ligase IV dependent.
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