GSK2636771GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines.
IC50 value:
Target:
in vitro: GSK-2636771 shows selectively inhibitory activity in PTEN null cell lines (human prostate adenocarcinoma PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively.
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Description: GSK2606414 GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM. IC50 Value: 0.4 nM [1] Target:PERK GSK2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Tar...
Description: GSK126 GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase with Ki value of 0.5 nM. IC50 Value: 0.5 nM (Ki) Target: EZH2 in vitro: Although GSK126 induced loss of H3K27me3 indepe...