Milbemycin oxime

Milbemycin oxime is active against a broad spectrum of nematodes, although it is less potent against heartworms than ivermectin. Its miticide spectrum includes Sarcoptes and Demodex. The USA FDA approval for milbemycin oxime as formulated alone does not indicate insecticidal activity.[1]
The substance is often combined with other parasiticides to achieve a broader spectrum of action. Such products include:
Milbemax (with praziquantel)
Sentinel Flavor Tabs (with lufenuron)
Trifexis (with spinosad)
Recently the drug has been used in marine reef aquaria to control parasitic harptacoid copepod (Tegastidae) infestations on captive hard coral colonies. It is an effective full tank treatment for these parasites because it is not toxic to corals in the dosage required to kill the parasites. Shrimps, crabs and other crustaceans should be removed prior to treatment, as they will be killed by the treatment.

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