Melanotan-II
Sequence: AC-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Alias: Melanotan II, 7)-lactam, AC-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2;AC-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10)-NH2
Molecular formula: C50H69N15O9
MW: 1024.180
CAS: 121062-08-6
PubChem: 92432
Grade: Pharmaceutical Grade
Purity: 98%
Appearance: White Powder
Storage: Closed, below 2?~ 8o C?preservation
Usage: Melanotan 2?has been shown in studies to exhibit appetite suppressant, lipolytic, and libido-enhancing effects in addition to promoting skin tanning. Melanotan 2?has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Description:
Melanotan may refer to one of two separate peptides: Afamelanotide, originally developed under the names "Melanotan-1" or "Melanotan I" for skin tanning, a?drug currently in trials in implant form as a?prophylactic treatment for a?series of light affected skin disorders and potential skin cancer preventative agent
Melanotan II, a?drug originally developed as a?skin tanning agent, but subsequently investigated as a?potential treatment for sexual dysfunction
Melanotan 2?(also referred to as Melanotan II) is a?synthetically produced variant of a?peptide hormone naturally produced in the body that stimulates melanogenesis, a?process responsible for pigmentation of the skin. This peptide hormone, called alpha-Melanocyte stimulating hormone or MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a?result, Melanotan 2?has been shown in studies to exhibit appetite suppressant, lipolytic, and libido-enhancing effects in addition to promoting skin tanning. Melanotan 2?has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Additionally, Melanotan 2?and a?similar synthetically produced variant, known as PT-141, have been studied at length as a?potential remedy for the treatment of sexual dysfunction; Specifically, male erectile dysfunction.
Application:
A few synthetic analogues of α?-MSH have been investigated for their apparent photoprotective effects against ultraviolet (UV) radiation from the sun, namely Melanotan (afamelanotide) and Melanotan II, referred to as Melanotan 2. Bremelanotide, another analogue of α?-MSH similar to Melanotan 2, is currently under development for the treatment of sexual dysfunction. All of these melanotan peptides have significantly greater potencies than α?-MSH, but with distinctive selectivity peptide profiles.
How it works?
Melanotan 2 works by stimulating the release of the pigment melanin from the skin.Less UV exposure is necessary with Melanotan 2 compared to "normal tanning", and the tan that occurs with tanning injections is deeper and longer lasting than an individual's "normal tan".Melanotan works best (has the most noticeable effects) on people with fair skin tones.
Melanotan 1 compared with Melanotan 2:
Melanotan 1 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin.Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects.Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors.As a result, Melanotan-1 sunless skin tanning effects.While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction, Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone (α -MSH) that tend to induce skin tanning.Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido.Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R, MC3-5R).As an analogue of α -MSH, its mechanism of action is biomimicry of the natural mammalian tanning process.
How to use Melanotan II for prosexual effect:
Where there is no physical erectile dysfunction and where at least some degree of psychological libido exists, Melanotan II can greatly increase the tendency to penile erection. The situation can even become like the years of puberty, where scarcely even the beginning of a sexual thought or even nothing at all (perhaps an unconscious thought however) produces an erection. General physical fatigue can become irrelevant. These effects will not occur for all individuals, but do occur for many.
Prosexual usage requires injection at least about 4-6 hours prior to desired effect. Duration of action can be about 6-12 hours after onset of effect.
Needed dosage is typically about 1 mg, but for some even 0.5 mg can be effective. As a guide, dosage should not exceed 2 mg.
Because of the associated effect in increasing tendency to tan, frequency of MT-II use for this purpose is generally limited. If wishing this effect frequently, a better choice is to use PT-141 (bremelanotide,) an MT-II derivative.
Melanotan 2 benefits :
Lasting Tan:Even if dosage is stopped, a warm sun-kissed tan can last for months at a time without any exposure to the sun.Conversely, tans developed naturally fade in around a months time.
Flexibility of Use:Able to take a small loading dose with continued dosing until desired skin pigmentation is achieved.Once achieved only need to dose once every couple of weeks to maintain same pigment.
Reduced exposure to sunlight (UV rays):Melanotan still needs exposure to sunlight to be effective.However it will allow the user a significant reduction in time to develop desired tan .
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