AZD1208AZD1208 is a novel, orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases and is currently undergoing Phase I testing and dose escalation studies in AML.
IC50 Value: < 5 nM
Target: pan-Pim kinase
AZD1208 suppresses the growth of MOLM 16 and KG 1 xenograft tumors in vivo in a dosedependent manner.
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Description: AZD3965 AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM. IC50 value: 1.6 nM(Ki) [1] Target: MCT-1 selective inhibitor Both l...
Description: AZD-7762 AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM; equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. IC50 Value: 5 nM Target: ChK in vitro: AZD-7762 is a novel checkpoint kinase inhibito...