Polypeptide 106612-94-6 GLP-1 (7-37) Acetate for Diabetes Mellitus
Product Description
Polypeptide Hormones GLP-1 CAS 106612-94-6 GLP-1 (7-37) Acetate For The Treatment of Type 2 Diabetes Mellitus
1. Quick Detail:
GLP-1 (7-37) Acetate
Sequence: His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Alias: 7-37-Glucagon-likepeptide I (human); Glucagon-relatedpeptide 1 (Rana catesbeiana), 3-L-glutamicacid-10-L-valine-16-glycine-17-L-glutamine-23-L-isoleucine-24-L-alanine-27-L-valine-31-glycine-32-de-L-lysine-
CAS No.: 106612-94-6
Molecular Formula: C151H228N40O47
Molecular Weight: 3355.74
Purity (HPLC): 98.0%
Appearance: White powder
Single Impurity (HPLC): 1.0%
Amino Acid Composition: 10% of theoretical
Peptide Content (N%): 80% (by %N)
Water Content (Karl Fischer): 6.0%
Acetate Content (HPIC): 15.0%
Grade: Pharmaceutical Grade
Storage: Closed, below 2 ~ 8o C preservation
Usage: GLP-1 can obviously improve the blood glucose in type 2 diabetes animal models or patients through a variety of mechanisms, which promote the regeneration and repair of islet beta cells, increase the number of beta cells is particularly significant role, provides a very good prospect for the treatment of type 2 diabetes mellitus.
2. Description:
Glucagon like peptide -1 (GLP-1) is a brain gut peptides secretion ileal endocrine cells, at present mainly as a target for type 2 diabetes drug action. Because GLP-1 can reduce the inhibition of gastric emptying, intestinal peristalsis, thus helps to control food intake, weight loss. Prospective placebo in 19 cases of obese patients in control, random, double-blind, crossover trial, GLP-1 subcutaneous injection can increase the patients with postprandial satiety, and make each meal diet weight average reduction of 15%. But because GLP-1 is a polypeptide, cannot be administered orally is a major shortcoming.
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3. Application:
1. Effect of GLP-1 GLP-1 can protect beta cells can act on the pancreatic beta cells, promote the synthesis of insulin, insulin gene transcription and secretion and can stimulate the proliferation and differentiation of islet beta cells, inhibit the apoptosis of pancreatic beta cells, increase the number of beta cell of islet [2-5]. In addition, GLP-1 also can be applied to the pancreatic alpha cells, strongly inhibit the release of glucagon, and act on the islet delta cells, promote the secretion of somatostatin, somatostatin cells and can be used as a paracrine hormone involved in the inhibition of glucagon.
2. GLP-1 with glucose concentration dependent hypoglycemic effect, i. e. Only rise in glucose levels under the condition of GLP-1, only play a hypoglycemic effect, but in normal blood sugar levels, caused no further decrease. The glucose concentration dependence of the GLP-1 is its hypoglycemic properties of clinical application safety of foundation and security, thereby avoiding people may cause severe hypoglycemia in patients with existing drug treatment for diabetes and scheme of worry.
3. In addition, GLP-1 also has many other biological characteristics and functions, for example, GLP-1 might play a lipid-lowering, antihypertensive effect, so as to have a protective effect on the cardiovascular system; It can also by acting on central reinforcement learning and memory function, protect the nerve.
4. Specification:
Product name GLP-1 (7-37) Acetate
Appearance White Powder
Assay 98%
Molecular formula C151H228N40O47
Molecular weight 3355.74
Package 2mg/vial or as your request
Shipping Fast and secure shipping by DHL,EMS,UPS , FedEx..
Shipping leading time Within 18 hours after receiving the payment
Payment Terms Western Union, Money Gram , T/T, PayPal
Price Negotiable
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