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BMS 777607

  • Purity: >98%
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:BMS 777607
  • CAS No: 1025720-94-8

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BMS 777607BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

IC50 value: 3.9/1.1/1.8/4.3 nM (c-Met/Axl/Ron/Tyro3) [1]

Target: c-Met/Axl/Ron/Tyro3

in vitro: BMS-777607 is a selective ATP-competitive Met kinase inhibitor which potently blocks the autophosphorylation of c-Met with IC50 of 20 nM in GTL-16 cell lysates, and demonstrates selective inhibition of proliferation in Met-driven tumor cell lines, such as GTL-16 cell line, H1993 and U87 [1].

Target:PI3K

Product Links:http://www.medchemexpress.cn/bms-777607.html

Permanent link:http://www.medchemexpress.com/BMS-777607.html

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