Home > Name List By 5 > 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]- N,N-dimethyl-1,2,4-triazole-3-carboxamide

CAS No 99593-25-6 , 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-
N,N-dimethyl-1,2,4-triazole-3-carboxamide

  • Name: 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-
    N,N-dimethyl-1,2,4-triazole-3-carboxamide
  • Synonyms: Rilmazafone [INN];Rilmazafonum [Latin]; Rilmazafone (INN); 99593-25-6;5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-
    N,N-dimethyl-1,2,4-triazole-3-carboxamide; rilmazafone hydrochloride; Rilmazafona [Spanish];
  • CAS Registry Number:
  • Density: 1.45g/cm3
  • Refractive index: 1.671
  • Molecular Weight: 475.3279
  • InchiKey: KYHFRCPLIGODFH-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H20Cl2N6O3/c1-28(2)21(32)20-26-17(11-25-18(30)10-24)29(27-
    20)16-8-7-12(22)9-14(16)19(31)13-5-3-4-6-15(13)23/h3-9H,10-11,24H2,
    1-2H3,(H,25,30)
  • Molecular Formula: C21H20Cl2N6O3
  • Molecular Structure:CAS No:99593-25-6 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-<br />N,N-dimethyl-1,2,4-triazole-3-carboxamide

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99593-25-6 1H-1,2,4-Triazole-3-carboxamide,5- [[(aminoacetyl)amino]methyl]-1-[4-chloro-2- (2-chlorobenzoyl)phenyl]-N,N-dimethyl-

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References of 5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-
N,N-dimethyl-1,2,4-triazole-3-carboxamide
Title: Rilmazafone
CAS Registry Number: 99593-25-6
CAS Name: 5-[[(Aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide
Synonyms: 1-(2-o-chlorobenzoyl-4-chlorophenyl)-5-glycylaminomethyl-3-dimethylcarbamoyl-1H-1,2,4-triazole; 2￠,5-dichloro-2-(3-dimethylcarbamoyl-5-glycylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone
Molecular Formula: C21H20Cl2N6O3
Molecular Weight: 475.33
Percent Composition: C 53.06%, H 4.24%, Cl 14.92%, N 17.68%, O 10.10%
Literature References: Ring-opened triazolobenzodiazepine derivative. Prepn: K. Hirai, H. Sugimoto, DE 2725164; eidem, US 4159374 (1977, 1979 both to Shionogi); and CNS activity: K. Hirai et al., J. Heterocycl. Chem. 19, 1363 (1982). Receptor binding study of rilmazafone and its closed ring active metabolites: M. Fujimoto et al., Biochem. Pharmacol. 33, 1645 (1984). Combined HPLC determn and enzyme immunoassay in plasma: G. Kominami et al., J. Chromatogr. 417, 216 (1987). Series of articles on teratogenicity studies: Oyo Yakuri 30, 749-833 (1985), C.A. 104, 81885h-81887k; 102328w (1986).
 
Derivative Type: Monohydrochloride dihydrate
Manufacturers' Codes: 450191-S
Trademarks: Rhythmy (Shionogi)
Molecular Formula: C21H20Cl2N6O3.HCl.2H2O
Molecular Weight: 547.82
Percent Composition: C 46.04%, H 4.60%, Cl 19.41%, N 15.34%, O 14.60%
Properties: Solid from 95% ethanol, mp 107°. LD50 orally in mice: >1500 mg/kg (Hirai, 1979).
Melting point: mp 107°
Toxicity data: LD50 orally in mice: >1500 mg/kg (Hirai, 1979)
 
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic.