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CAS No 98048-97-6 , Fosinopril Search by region : China

  • Name: Fosinopril
  • Synonyms: Fosinopril;4-Cyclohexyl-1-[2-[(2-methyl-1-propanoyloxy-propoxy)-(4-phenylbutyl)phosphoryl]acetyl];4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxy-propoxy)-(4-phenylbutyl)phosphoryl]acetyl];
  • CAS Registry Number:
  • Melting Point: 149-153 ºC
  • Density: 1.173 g/cm3
  • Refractive index: 1.531
  • Molecular Weight: 563.66
  • InChI: InChI=1/C30H46NO7P/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)/t25-,26+,30?,39?/m1/s1
  • Molecular Formula: C30H46NO7P
  • Molecular Structure:CAS No:98048-97-6 Fosinopril

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References of Fosinopril
Title: Fosinopril
CAS Registry Number: 98048-97-6
CAS Name: (4S)-4-Cyclohexyl-1-[[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline
Synonyms: (4S)-4-cyclohexyl-1-[[[(RS)-1-hydroxy-2-methylpropoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline propionate (ester); fosenopril
Molecular Formula: C30H46NO7P
Molecular Weight: 563.66
Percent Composition: C 63.93%, H 8.23%, N 2.48%, O 19.87%, P 5.50%
Literature References: Phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Prepn: E. W. Petrillo, Jr., US 4337201 (1982 to Squibb); of active diacid form: J. Krapcho et al., J. Med. Chem. 31, 1148 (1988). Metabolism and pharmacokinetics: S. M. Singhvi et al., Br. J. Clin. Pharmacol. 25, 9 (1988). GC determn of diacid: M. Jemal et al., J. Chromatogr. 345, 299 (1985). Clinical trial in hypertension: P. A. Sullivan et al., Am. J. Hypertens. 1, 280S (1988). Brief description: E. W. Petrillo, Jr., et al., Clin. Exp. Theory Prac. A9, 235 (1987). Series of articles on pharmacology, pharmacokinetics, and clinical experience: Drug Invest. 3, Suppl. 4, 1-53 (1991).
 
Derivative Type: Sodium salt
CAS Registry Number: 88889-14-9
Manufacturers' Codes: SQ-28555
Trademarks: Dynacil (Schwarz); Elidiur (BMS); Fosinorm (BMS); Fositen (BMS); Fozitec (Lipha); Monopril (BMS); Staril (BMS); Tensozide (Mead Johnson)
Molecular Formula: C30H45NNaO7P
Molecular Weight: 585.64
Percent Composition: C 61.53%, H 7.74%, N 2.39%, Na 3.93%, O 19.12%, P 5.29%
 
Derivative Type: Diacid
CAS Registry Number: 95399-71-6
Manufacturers' Codes: SQ-27519
Molecular Formula: C23H34NO5P
Molecular Weight: 435.49
Percent Composition: C 63.43%, H 7.87%, N 3.22%, O 18.37%, P 7.11%
Properties: mp 149-153°. [a]D -24° (c = 1 in methanol).
Melting point: mp 149-153°
Optical Rotation: [a]D -24° (c = 1 in methanol)
 
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.