Home > Name List By other > [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1, 3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate

CAS No 97240-79-4 , [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,
3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate

  • Name: [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,
    3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate
  • Synonyms: Topina; Tipiramato [Spanish]; Tipiramate [French]; Epitomax;[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,
    3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate; Topamax Sprinkle; Topimax; McN-4853;Topamax; Topomax;
  • CAS Registry Number:
  • Melting Point: 125 ºC
  • Density: 1.336 g/cm3
  • Refractive index: 1.497
  • Water Solubility: DMSO Solubility : ~44 mg/mL
  • Safety Statements: 26-36
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 339.36204
  • InchiKey: KJADKKWYZYXHBB-XBWDGYHZSA-N
  • InChI: InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,
    14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,
    8-,9+,12+/m1/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C12H21NO8S
  • Molecular Structure:CAS No:97240-79-4 [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,<br />3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate

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References of [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,
3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate
Title: Topiramate
CAS Registry Number: 97240-79-4
CAS Name: 2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamate
Synonyms: 2,3:4,5-di-O-isopropylidene-b-D-fructopyranose sulfamate
Manufacturers' Codes: McN-4853; RWJ-17021-000
Trademarks: Topamax (J & J)
Molecular Formula: C12H21NO8S
Molecular Weight: 339.36
Percent Composition: C 42.47%, H 6.24%, N 4.13%, O 37.72%, S 9.45%
Literature References: Sulfamate substituted monosaccharide; structurally distinct antiepileptic agent. Prepn: B. E. Maryanoff, J. F. Gardocki, US 4513006 (1985 to McNeil); and anticonvulsant activity: B. E. Maryanoff et al., J. Med. Chem. 30, 880 (1987). GC determn in plasma: M. L. Holland et al., J. Chromatogr. 433, 276 (1988). Comparative pharmacokinetics: M. Bialer, Clin. Pharmacokinet. 24, 441 (1993). Series of articles on pharmacology and clinical experience in epilepsy: Epilepsia 38, Suppl. 1, 1-62 (1997). Review of clinical trials in migraine prevention: G. Bussone et al., Int. J. Clin. Pract. 59, 961-968 (2005); of pharmacology and clinical experience: S. D. Silberstein et al., Clin. Ther. 27, 154-165 (2005).
Properties: Crystals from ethyl acetate + hexane, mp 125-126°. [a]D23 -34.0° (c = 0.4 in methanol).
Melting point: mp 125-126°
Optical Rotation: [a]D23 -34.0° (c = 0.4 in methanol)
Therap-Cat: Anticonvulsant; antimigraine.
Keywords: Anticonvulsant; Antimigraine.