Home > Name List By 1 > 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S,3S)-

CAS No 96125-53-0 , 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S,3S)-

  • Name: 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S,3S)-
  • Synonyms: 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S-cis)-;Clentiazem;1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S,3S)-;(+)-cis-2-(4-Methoxyphenyl)-3-acetoxy-5-[2-(N,N-dimethylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one;
  • CAS Registry Number:
  • Flash Point: 332.7°C
  • Boiling Point: 626.4°Cat760mmHg
  • Density: 1.32g/cm3
  • Flash Point: 332.7°C
  • Molecular Weight: 0
  • InChI: InChI=1/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1
  • Molecular Formula: C22H25 Cl N2 O4 S

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References of 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S,3S)-
Title: Clentiazem
CAS Registry Number: 96125-53-0
CAS Name: (2S,3S)-3-(Acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Synonyms: (+)-(2S,3S)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester)
Molecular Formula: C22H25ClN2O4S
Molecular Weight: 448.96
Percent Composition: C 58.85%, H 5.61%, Cl 7.90%, N 6.24%, O 14.25%, S 7.14%
Literature References: Calcium channel blocker; 8-chloro derivative of diltiazem. Prepn: M. Takeda et al., EP 127882; eidem, US 4567175 (1984, 1986 both to Tanabe); H. Inoue et al., J. Med. Chem. 34, 675 (1991). Cardiovascular pharmacology: H. Narita et al., Arzneim.-Forsch. 38, 515 (1988). Clinical pharmacokinetics: A. K. Shah et al., J. Clin. Pharmacol. 33, 354 (1993). Clinical evaluation in hypertension: S. Kawakita et al., Clin. Cardiol. 14, 53 (1991).
 
Derivative Type: Maleate
CAS Registry Number: 96128-92-6
Manufacturers' Codes: TA-3090
Trademarks: Logna (Tanabe)
Molecular Formula: C22H25ClN2O4S.C4H4O4
Molecular Weight: 565.04
Percent Composition: C 55.27%, H 5.17%, Cl 6.27%, N 4.96%, O 22.65%, S 5.67%
Properties: Crystals from ethanol, mp 160.5-161.5°. [a]D20 +76.5° (c = 1 in methanol).
Melting point: mp 160.5-161.5°
Optical Rotation: [a]D20 +76.5° (c = 1 in methanol)
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Calcium Channel Blocker; Benzothiazepines.